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Collagenase References

Source:
Clostridium histolyticum
CAS:
9001-12-1
EC:
3.4.24.3
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Abe, S. and Nagai, Y.
Evidence for the Presence of a Complex of Collagenase with alpha-2-Macroglobulin in Human Rheumatoid Synovial Fluid: A Possible Regulatory Mechanism of Collagenase Activity ,
J. Biochem.
 73 , 897 , 1973
Adams, E. , Antoine, S. and Golstein, A.
Collagenase Action on the Synthetic Tripeptide Polymers, (Gly-Pro-Ala)n and (Gly-Ala-Pro)n ,
Biochim Biophys Acta
 185 , 251 , 1969
Ala-aho, R. and Kahari, V.
Collagenases in Cancer ,
Biochimie
 87 , 273 , 2005
Amsterdam, A. and Jamieson, J.
Studies on Dispersed Pancreatic Exocrine Cells. II. Functional Characteristics of Separated Cells ,
J Cell Biol
 63 , 1057 , 1974
An Editorial.
Collagenase and Rheumatoid Arthritis ,
N Engl J Med
 279 , 942 , 1968
Angleton, E. and Van Wart, H.
Preparation and Reconstitution with Divalent Metal Ions of Class I and Class II Clostridium histolyticum Apocollagenases ,
Biochemistry
 27 , 7406 , 1988
Ashcroft, S. , Bassett, J. and Randle, P.
Isolation of Human Pancreatic Islets Capable of Releasing Insulin and Metabolising Glucose in vitro ,
Lancet
 297 , 888 , 1971
Bagchi, N.
What Makes Silica Toxic ,
Br J Industrial Med
 49 , 163 , 1992
Barker, C.
Transplantation of the Islets of Langerhans and the Histocompatibility of Endocrine Tissue ,
Diabetes
 24 , 766 , 1975
Barrett, A. , Knight, C. , Brown, M. and Tisljar, U.
A Continuous Fluorimetric Assay for Clostridial Collagenase and Pz-peptidase Activity ,
Biochem J
 260 , 259 , 1989
Bauer, E. , Eisen, A. and Jeffrey, J.
Immunologic Relationship of a Purified Human Skin Collagenase to Other Human and Animal Collagenases ,
Biochim Biophys Acta
 206 , 152 , 1970
Bauer, E. , Eisen, A. and Jeffrey, J.
Studies on Purified Rheumatoid Synovial Collagenase in Vitro and in vivo ,
J Clin Invest
 50 , 2056 , 1971
Bauer, E. , Jeffrey, J. and Eisen, A.
Preparation of Three Vertebrate Collagenases in Pure Form ,
Biochem Biophys Res Commun
 44 , 813 , 1971
Bauer, E. , Stricklin, G. , Jeffrey, J. and Eisen, A.
Collagenase Production by Human Skin Fibroblasts ,
Biochem Biophys Res Commun
 64 , 232 , 1975
Bensusan, H.
An Investigation of the Products of an Enzymatic Hydrolysis of Collagens ,
Biochemistry
 8 , 4716 , 1969
Benya, P. , Berger, K. , Golditch, M. and Schneir, M.
Recommendations Concerning the Use of Bacterial Collagenase for Isolating Collagen-Associated Molecules from Tissues ,
Anal Biochem
 53 , 313 , 1973
Bergmann, U. , Michaelis, J. , Oberhoff, R. , Knauper, V. , Beckmann, R. and Tschesche, H.
Enzyme Linked Immunosorbent Assays (ELISA) for the Quantitative Determination of Human Leukocyte Collagenase and Gelatinase (Original Paper) ,
J Clin Chem Clin Biochem
 27 , 351 , 1989
Berry, L. and Shuttleworth, C.
Bacterial Collagenase and Collagen Identification ,
Conn Tissue Res
 17 , 153 , 1988
Berry, M. and Friend, D.
High Yield Preparation of Isolated Rat Liver Parenchymal Cells ,
J Cell Biol
 43 , 506 , 1969
Bicsak, T. and Harper, E.
Purification and Characterization of Tadpole Back-Skin Collagenase with Low Gelatinase Activity ,
J Biol Chem
 259 , 13145 , 1984
Bienkowski, R. , Curran, S. and Berg, R.
Kinetics of Intracellular Degradation of Newly Synthesized Collagen ,
Biochemistry
 25 , 2455 , 1986
Birkedal-Hansen, H.
, Methods Enzymol. Vol. 144 , 140 , 1987
Blanckaert, A. , Mazieres, B. , Eeckhout, Y. and Vaes, G.
Direct Extraction and Assay of Collagenase from Human Osteoarthritic Articular Cartilage ,
Clin Chim Acta
 185 , 73 , 1989
Bols, M. , Binderup, L. , Hansen, J. and Rasmussen, P.
Inhibition of Collagenase by Aranciamycin and Aranciamycin Derivatives ,
J Med Chem
 35 , 2768 , 1992
Bond, M. and Van Wart, H.
Purification and Separation of Individual Collagenases of Clostridium histolyticum Using Red Dye Ligand Chromatography ,
Biochemistry
 23 , 3077 , 1984
Bond. M. and Van Wart, H.
Characterization of the Individual Collagenases from Clostridium histolyticum ,
Biochemistry
 23 , 3085 , 1984
Bond. M. and Van Wart, H.
Relationship between the Individual Collagenases of Clostridium histolyticum: Evidence for Evolution by Gene Duplication ,
Biochemistry
 23 , 3092 , 1984
Brady, A.
Collagenase in Scleroderma ,
J Clin Invest
 56 , 1175 , 1975
Brandhorst, H. , Brandhorst, D. , Hering, B. and Bretzel, R.
Significant Progress in Porcine Islet Mass Isolation Utilizing Liberase HI for Enzymatic Low-Temperature Pancreas Digestion ,
Transplantation
 68 , 355 , 1999
Bruns, R. and Gross, J.
Band Pattern of the Segment-Long-Spacing Form of Collagen. Its Use in the Analysis of Primary Structure ,
Biochemistry
 12 , 808 , 1973
Callaway, J. , Garcia, J. , Hersh, C. , Yeh, R. and Gilmore-Hebert, M.
Use of Lectin Affinity Chromatography for the Purification of Collagenase from Human Polymorphonuclear Leukocytes ,
Biochemistry
 25 , 4757 , 1986
Carrick, L. and Berk, R.
Purification and Partial Characterization of a Collagenolytic Enzyme from Pseuodomonas aeruginosa ,
Biochim Biophys Acta
 391 , 422 , 1975
Cawston, T.
Measurement of activity of collagenolytic MMP and inhibitors of MMPs using radiolabeled collagen substrate ,
Nat Protoc
 4 , 286 , 2009
Chesney, C. , Harper, E. and Colman, R.
Human Platelet Collagenase ,
J Clin Invest
 53 , 1647 , 1974
Chu, K.
Collagenase Chemonucleolysis via Epidural Injection. A Review of 252 Cases ,
Clin Orthop
 215 , 99 , 1987
Connell, J. and Rousselot, L.
Use of Enzymatic Agents in Debridement of Burn and Wound Sloughs ,
Surgery
 30 , 43 , 1951
Contractor, H. , Johnson, P. , Chadwick, D. , Robertson, G. and London, N.
The Effect of UW Solution and its Components on the Collagenase Digestion of Human and Porcine Pancreas ,
Cell Transplant
 4 , 615 , 1995
Czech, M. and Fain, J.
Dactinomycin Inhibition of Dexamethasone Action on Glucose Metabolism in White Fat Cells ,
Biochim Biophys Acta
 230 , 185 , 1971
De Oca, H. and Malinin, T.
Dispersion and Cultivation of Renal Cells After Short-Term Storage of Kidneys ,
J Clin Microbiol
 2 , 243 , 1975
De Souza, S. , Pereira, H. , Jacchieri, S. and Brentani, R.
Collagen/Collagenase Interaction: Does the Enzyme Mimic the Conformation of Its Own Substrate? ,
FASEB J
 10 , 927 , 1996
DeBellis, R. , Mandl, I. , MacLennan, J. and Howes, E.
Separation of Proteolytic Enzymes of Clostridium histolyticum ,
Nature
 174 , 1191 , 1954
Dono, K. , Gotoh, M. , Fukuzaki, T. , Ohzato, H. , Kanai, T. , Monden, M. and Mori, T.
Low-Temperature Collagenase Digestion: An Improved Islet Isolation Method from Cold Preserved Pancreas ,
Transplant Proc
 24 , 1511 , 1992
Donoff, R. , McLenan, J. and Grillo, H.
Preparation and Properties of Collagenases from Epithelium and Mesenchyme of Healing Mammalian Wounds ,
Biochim Biophys Acta
 227 , 639 , 1971
Dresden, M.
Evidence for the Role of Collagenase in Collagen Metabolism ,
Nature New Biol
 231 , 55 , 1971
Ducka, P. , Eckhard, U. , Schonauer E. , Kofler, S. , Gottschalk, G. , Brandstetter, H. and Nüss, D.
A Universal Strategy for High-yield Production of Soluble and Functional Clostridial Collagenases in E. coli ,
Appl Microbiol Biotechnol
 e-pub , ahead of print , 2009
Eckhard, U. , Nüss, D. , Ducka P. , Schonauer E. and Brandstetter, H.
Crystallization and Preliminary X-ray Characterization of the Catalytic Domain of Collagenase G from Clostridium histolyticum . ,
Acta Crystallogr Sect F Struct Biol Cryst Commun
 64 , 419 , 2008
Eckhard, U. , Schonauer, E. , Ducka, P. , Briza, P. , Nüss, D. and Brandstetter, H.
Biochemical Characterization of the Catalytic Domains of Three Different Clostridial Collagenases ,
Biol. Chem.
 390 , 11 , 2009
Eckhard, U. , Schonauer, E. , Nüss, D. and Brandstetter, H.
Structure of Collagenase G Reveals a Chew-and-Digest Mechanism of Bacterial Collagenolysis ,
Nat. Struct. Mol. Biol.
 18 , 1109 , 2011
Eckhard, U. , Schonauer, E. and Brandstetter, H.
Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T. ,
J Biol Chem
 288 , 20184-94 , 2013
Eisen, A. , Bloch, K. and Sakai, T.
Inhibition of Human Skin Collagenase by Human Serum ,
J Lab Clin Med
 75 , 258 , 1970
Eisen, A. , Henderson, K. , Jeffrey, J. and Bradshaw, R.
A Collagenolytic Protease from the Hepatopancreas of the Fiddler Crab Uca pugilator. Purification and Properties ,
Biochemistry
 12 , 1814 , 1973
Eisen, A. , Jeffrey, J. and Gross, J.
Human Skin Collagenase, Isolation and Mechanism of Attack on the Collagen Molecule ,
Biochim Biophys Acta
 151 , 637 , 1968
Eisen, A. , Bauer, E. and Jeffrey, J.
Human Skin Collagenase. The Role of Serum Alpha-Globulins in the Control of Activity in vivo and in vitro ,
Proc Natl Acad Sci U S A
 68 , 248 , 1971
Ellis, S. , Nabeshima, K. and Biswas, C.
Monoclonal Antibody Preparation and Purification of a Tumor Cell Collagenase-Stimulatory Factor ,
Cancer Res
 49 , 3385 , 1989
Elsbach, P. and Rizack, M.
The Effect of Collagenase Preparations Contaminated with Phospholipase C Activity on Adipose Tissue Lecithin ,
Biochim Biophys Acta
 198 , 82 , 1970
Emod, I. , Tong, N. and Keil, B.
Chemical Characterization of the Homogeneous Collagenase from Clostridium histolyticum ,
Biochim Biophys Acta
 659 , 283 , 1981
Evanson, J. , Jeffrey, J. and Krane, S.
Collagenase and Rheumatoid Arthritis ,
N Engl J Med
 279 , 942 , 1968
Evanson, J. , Jeffrey, J. and Krane, S.
Studies on Collagenase from Rheumatoid Synovium in Tissue Culture ,
J Clin Invest
 47 , 2639 , 1968
Ewadh, M. , Tudball, N. and Rose, F.
Homocysteine Uptake by Human Umbilical Vein Endothelial Cells in Culture ,
Biochim Biophys Acta
 1054 , 263 , 1990
Ewart, R. , Kornfeld, S. and Kipnis, D.
Effect of Lectins on Hormone Release from Isolated Rat Islets of Langerhans ,
Diabetes
 24 , 705 , 1975
Fields, G.
Interstitial collagen catabolism. ,
J Biol Chem
 288 , 8785-93 , 2013
Foley, J. and Aftonomos, B.
Growth of Human Breast Neoplasms in Cell Culture ,
J Natl Cancer Inst
 34 , 217 , 1965
Fox, C. , Stanford, J. and Sampath, A.
Topical Use of Collagenase with Silver Sulfadiazine in Burns , Collagenase , I. Mandl , Gordon and Breach, NY , 145 , 1972
French, M. , Bhown, A. and Van Wart, H.
Identification of Clostridium histolyticum Collagenase Hyperreactive Sites in Type I, II, and III Collagens: Lack of Correlation with Local Triple Helical Stability. ,
J Protein Chem
 11 , 83 , 1992
French, M. , Mookhtiar, K. and Van Wart, H.
Limited Proteolysis of Type I Collagen at Hyperreactive Sites by Class I and II Clostridium histolyticum Collagenases: Complementary Digestion Patterns ,
Biochemistry
 26 , 681 , 1987
Fujiwara, K. , Sakai, T. , Oda, T. and Igarashi, S.
Demonstration of Collagenase Activity in Rat Liver Homogenate ,
Biochem Biophys Res Commun
 60 , 166 , 1974
Galardy, R. and Grobelny, D.
Inhibition of Collagenase from Clostridium histolyticum by Phosphoric and Phosphonic Amides ,
Biochemistry
 22 , 4556 , 1983
Gallop, P. , Seifter, S. and Meilman, E.
Studies on Collagen. I. The Partial Purification, Assay, and Mode of Activation of Bacterial Collagenase ,
J Biol Chem
 227 , 891 , 1957
Gates, R. , Hunt, M. , Smith, R. and Lazarus, N.
Return to Normal of Blood-Glucose, Plasma Insulin, and Weight Gain in New Zealand Obese Mice after Implantation of Islets of Langerhans ,
Lancet
 300 , 567 , 1972
Gisslow, M. and McBride, B.
A Rapid Sensitive Collagenase Assay ,
Anal Biochem
 68 , 70 , 1975
Gonzales, T. and Robert-Baudouy, J.
Bacterial Aminopeptidases: Properties and Functions. ,
FEMS Microbiol Rev
 18 , 319 , 1996
Gottlieb, A. , Peterkofsky, B. and Udenfriend, S.
Use of Collagenase to Identify Enzymatically Formed Collagen and a Hydroxyproline-Deficient Intermediate ,
J Biol Chem
 240 , 3099 , 1965
Grant, N. and Alburn, H.
Collagen Solubilization by Mammalian Proteinases ,
Arch Biochem Biophys
 89 , 262 , 1960
Grant, N. and Alburn, H.
Studies on the Collagenase of Clostridium histolyticum ,
Arch Biochem Biophys
 82 , 245 , 1959
Gray, D. , McShane, P. , Grant, A. and Morris, P.
A Method for Isolation of Islets of Langerhans from the Human Pancreas ,
Diabetes
 33 , 1055 , 1984
Grobelny, D. and Galardy, R.
Aldehyde and Ketone Substrate Analogues Inhibit the Collagenase of Clostridium histolyticum ,
Biochemistry
 24 , 6145 , 1985
Gross, J. , Harper, E. , Harris, E. , McCroskery, P. , Highberger. J. , Corbett, C. and Kang, A.
Animal Collagenases: Specificity of Action, and Structures of the Substrate Cleavage Site ,
Biochem Biophys Res Commun
 61 , 605 , 1974
Gross, J. and Lapiere, C.
Collagenolytic Activity in Amphibian Tissues: A Tissue Culture Assay ,
Proc Natl Acad Sci U S A
 48 , 1014 , 1962
Gross, J.
How Tadpoles Lose Their Tails: Path to Discovery of the First Matrix Metalloproteinase ,
Matrix Biol
 3 , 3 , 2004
Grubb, J.
Assays for Bacterial Type I Collagenases ,
Meth Enzymol
 235 , 594 , 1994
Hamit, H. and Upjohn, H.
Debridement of Experimental Burns with Clostridium histolyticum H-4 Enzyme ,
Ann Surg
 151 , 589 , 1960
Han, H. , Taki, T. , Kondo, H. , Hirono, I. and Aoki, T.
Pathogenic Potential of a Collagenase Gene from Aeromonas veronii ,
Can J Microbiol
 54 , 1 , 2008
Han, S. , Blumenfeld, O. and Seifter, S.
Specific Identification of Collagens and Their Fragments by Clostridial and Anti-Collagenase Antibody ,
Anal Biochem
 201 , 336 , 1992
Harper, E.
Collagenases ,
Annu Rev Biochem
 49 , 1063 , 1980
Harper, E. and Gross, J.
Collagenase, Procollagenase and Activator Relationships in Tadpole Tissue Cultures ,
Biochem Biophys Res Commun
 48 , 1147 , 1972
Harper, E. and Kang, A.
Studies on the Specificity of Bacterial Collagenase ,
Biochem Biophys Res Commun
 41 , 482 , 1970
Harper, E. , Bloch, K. and Gross, J.
The Zymogen of Tadpole Collagenase ,
Biochemistry
 10 , 3035 , 1971
Harper, E. , Seifter, S. and Hospelhorn, V.
Evidence for Subunits in Bacterial Collagenase ,
Biochem Biophys Res Commun
 18 , 627 , 1965
Harris, E. and Krane, S.
Collagenases ,
N Engl J Med
 291 , 557 , 1974
Harris, E. and McCroskery, P.
The Influence of Temperature and Fibril Stability on Degradation of Cartilage Collagen by Rheumatoid Synovial Collagenase ,
N Engl J Med
 290 , 1 , 1974
Harris, E. , DiBona, D. and Krane, S.
Collagenases of Human Synovial Fluid ,
J Clin Invest
 48 , 2104 , 1969
Harris, E. , Faulkner, C. and Wood, S.
Collagenase in Carcinoma Cells ,
Biochem Biophys Res Commun
 48 , 1247 , 1972
Harris, E. and Farrell, M.
Resistance to Collagenase: A Characteristic of Collagen Fibrils Cross-Linked by Formaldehyde ,
Biochim Biophys Acta
 278 , 133 , 1972
Hausmann, E. and Kaufman, E.
Collagenase Activity in a Particulate Fraction from Bacillus melaninogenicus ,
Biochim Biophys Acta
 194 , 612 , 1969
Hayward, N.
Collagenase Maceration of Kidney for Micro-Dissection ,
Nature
 186 , 403 , 1960
Heindl, M. , Fermandjian, S. and Keil, B.
Circular Dichroism Comparative Studies of Two Bacterial Collagenases and Thermolysin ,
Biochim Biophys Acta
 624 , 51 , 1980
Hemminki, K.
An Improved Method for Preparing Brain Cell Suspensions ,
F.E.B.S. Lett.
 9 , 290 , 1970
Hersh, C. , Yeh, R. , Callaway, J. , Garcia, J. and Gilmore-Herbert, M.
Induction of Collagenase Production in U937 Cells by Phorbol Ester and Partial Purification of the Induced Enzyme ,
Biochemistry
 25 , 4750 , 1986
Hilfer, S. and Brown, J.
Collagenase. Its Effectiveness as a Dispersing Agent for Embryonic Chick Thyroid and Heart ,
Exp Cell Res
 65 , 246 , 1971
Hoover, N. and Ivins, J.
Wound Debridement ,
Arch Surg
 79 , 701 , 1959
Houck, J. and Patel, Y.
Collagenolytic Activity of Mammalian Pancreas ,
Proc Soc Exp Biol Med
 116 , 382 , 1964
Howard, R. , Christensen, A. , Gibbs, F. and Pesch, L.
The Enzymatic Preparation of Isolated Intact Parenchymal Cells from Rat Liver ,
J Cell Biol
 35 , 675 , 1967
Howes, E.
Use of Proteolytic Enzymes as Debriding Agents ,
Surgery
 42 , 948 , 1957
Howes, E. , MacLennan, J. , Mandl, I. and De Bellis, R.
Debridement of Burn Slough by Peptidases Recovered from Clostridium histolyticum ,
Bull NY Acad Med
 31 , 413 , 1955
Howes, E. , Mandl, I. , Zaffuto, S. and Ackermann, W.
The Use of Clostridium histolyticum Enzymes in the Treatment of Experimental Third Degree Burns ,
Surg Gyn Obs
 109 , 177 , 1959
Huang, C. and Abramson, M.
Purification and Characterization of Collagenase from Guinea Pig Skin ,
Biochim Biophys Acta
 384 , 484 , 1975
Jeffrey, J. and Gross, J.
Collagenase from Rat Uterus. Isolation and Partial Characterization ,
Biochemistry
 9 , 268 , 1970
Jozwiak, J. , Grzela, T. , Jankowska-Steifer, E. , Komar, A. , Moskalewski S. and Martirosian, G.
Lethal Factor of Clostridium histolyticum Kills Cells by Apoptosis. ,
FEMS Immunol Med Microbiol
 49 , 296-303 , 2007
Jung, C. , Matsushita, O. , Katayama, S. , Minami, J. , Sakurai, J. and Okabe, A.
Identification of Metal Ligands in the Clostridium histolyticum ColH Collagenase ,
J Bacteriol
 181 , 2816 , 1999
Kang, A. , Nagai, Y. , Piez, K. and Gross, J.
Studies on the Structure of Collagen Utilizing a Collagenolytic Enzyme from Tadpole ,
Biochemistry
 5 , 509 , 1966
Karakiulakis, G. , Papadimitriu, E. , Missirlis, E. and Maragoudakis, M.
Effect of Divalent Metal Ions on Collagenase from Clostridium histolyticum ,
Biochem Int
 24 , 397 , 1991
Keil, B.
Some Newly Characterized Collagenases from Procaryotes and Lower Eucaryotes ,
Mol Cell Biochem
 23 , 87 , 1979
Keil, B. , Gilles, A. , Lecroisey, A. , Hurion, N. and Tong, N.
Specificity of Collagenase from Achromobacter iophagus ,
F.E.B.S. Lett.
 56 , 292 , 1975
Keller, S. and Mandl, I.
The Preparation of Purified Collagenase ,
Arch Biochem Biophys
 101 , 81 , 1963
Kerwar, S. , Nolan, J. , Ridge, S. , Oronsky, A. and Slakey, L.
Properties of a Collagenase Inhibitor Partially Purified from Cultures of Smooth Muscle Cells ,
Biochim Biophys Acta
 632 , 183 , 1980
Kessler, E. and Yaron, A.
A Novel Aminopeptidase from Clostridium histolyticum ,
Biochem Biophys Res Commun
 50 , 405 , 1973
Kin, T. , Johnson, P. , Shapiro, A. and Lakey, J.
Factors Influencing the Collagenase Digestion Phase of Human Islet Isolation. ,
Transplantation
 83 , 7 , 2007
Kitabachi, A. , Wilson, D. and Sharma, R.
Steriodogenesis in Isolated Adrenal Cells of Rat. II. Effect of Caffeine on ACTH and Cyclic Nucleotide-Induced Steroidogenesis and Its Relation to Cyclic Nucleotide Phosphodiesterase (PDE) ,
Biochem Biophys Res Commun
 44 , 898 , 1971
Koebe, H. , Muhling, B. , Deglmann, C. and Schildberg, F.
Cryopreserved Porcine Hepatocyte Cultures ,
Chem Biol Interact
 121 , 99 , 1999
Kono, T.
Roles of Collagenases and Other Proteolytic Enzymes in the Dispersal of Animal Tissues ,
Biochim Biophys Acta
 178 , 397 , 1969
Kono, T.
Purification and Partial Characterization of Collagenolytic Enzyme from Clostridium histolyticum ,
Biochemistry
 7 , 1106 , 1968
Kruze, D. and Wojtecka, E.
Activation of Leucocyte Collagenase Proenzyme by Rheumatoid Synovial Fluid ,
Biochim Biophys Acta
 285 , 436 , 1972
Kula, M. , Hatef-Haghi, D. , Tauber-Finkelstein, M. and Shaltiel, S.
Consecutive Use of omega-Aminoalkylagaroses. Resolution and Purification of Clostripain and Collagenase from Clostridium histolyticum ,
Biochem Biophys Res Commun
 69 , 389 , 1976
Lasfargues, E. and Ozzello, L.
Cultivation of Human Breast Carcinomas ,
J Natl Cancer Inst
 21 , 1131 , 1958
Lasfargues, E.
Cultivation and Behavior in vitro of the Normal Mammary Epithelium of the Adult Mouse ,
Anat Rec
 127 , 117 , 1957
Lasfargues, E.
Collagenase-Treated Skin Autografts for Rapid Healing of Burns , Collagenase , I. Mandl , Gordon and Breach, NY , 151 , 1972
Lazarus, G. , Brown, R. , Daniels, J. and Fullmer, H.
Human Granulocyte Collagenase ,
Science
 159 , 1483 , 1968
Lazarus, G. , Daniels, J. , Brown, R. , Bladen, H. and Fullmer, H.
Degradation of Collagen by a Human Granulocyte Collagenolytic System ,
J Clin Invest
 47 , 2622 , 1968
Lee-Own, V. and Anderson, J.
The Preparation of a Bacterial Collagenase Containing Negligible Non-Specific Protease Activity ,
Prep Biochem
 5 , 229 , 1975
Lefebvre, V. and Vaes, G.
The Enzymatic Evaluation of Procollagenase and Collagenase Inhibitors in Crude Biological Media ,
Biochim Biophys Acta
 992 , 355 , 1989
Leibovich, S. and Weiss, J.
Failure of Human Rheumatoid Synovial Collagenase to Degrade Either Normal or Rheumatoid Arthritic Polymeric Collagen ,
Biochim Biophys Acta
 251 , 109 , 1971
Lin, M. and Chen, Y.
Effect of Copper Ion on Collagenase Release - Its Implication in Corneal Vascularizaton ,
Inv Ophthal Visual Sci
 33 , 558 , 1992
Liotta, L. , Lanzer, W. and Garbisa, S.
Identification of a Type V Collagenolytic Enzyme ,
Biochem Biophys Res Commun
 98 , 184 , 1981
Lwebuga-Mukasa, J. , Harper, E. and Taylor, P.
Collagenase Enzymes from Clostridium: Characterizaiton of Individual Enzymes ,
Biochemistry
 15 , 4736 , 1976
MacLennan, J. , Mandl, I. and Howes, E.
Bacterial Digestion of Collagen ,
J Clin Invest
 32 , 1317 , 1953
Makinen, P. and Makinen, K.
Near Stoichiometric, Irreversible Inactivation of Bacterial Collagenases by o-Chloranil (3,4,5,6-Tetrachloro-1,2-benzoquinone) ,
Biochem Biophys Res Commun
 153 , 74 , 1988
Mallya, S. , Mookhtiar, K. and Van Wart, H.
Kinetics of Hydrolysis of Type I, Type II, and Type III Collagens by the Class I and Class II Clostridium histolyticum Collagenases ,
J Protein Chem
 11 , 99 , 1992
Mandl, I. , MacLennan, J. , Howes, E. , DeBellis, R. and Sohler, A.
Isolation and Characterization of Proteinase and Collagenase from Cl. histolyticum ,
J Clin Invest
 32 , 1323 , 1953
Mandl, I. , Zipper, H. and Ferguson, L.
Clostridium histolyticum Collagenase: Its Purification and Properties ,
Arch Biochem Biophys
 74 , 465 , 1958
Mandl, I.
Collagenase ,
Science
 169 , 1234 , 1970
Mandl, I.
Collagenases and Elastases , Advances in Enzymology Vol. 23 , F. Nord , Interscience Publ., NY , 163 , 1961
Mandl, I. , Keller, S. and Manahan J.
Multiplicity of Clostridium histolyticum Collagenases ,
Biochemistry
 3 , 1737 , 1964
Matsushita O, Jung CM, Minami J, Katayama S, Nishi N, Okabe A.
A study of the collagen-binding domain of a 116-kDa Clostridium histolyticum collagenase. ,
J Biol Chem
 273 , 3643-8 , 1998
Matsushita, O. , Yoshihara, K. , Katayama, S. , Minami, J. and Okabe, A.
Purification and Characterization of a Clostridium perfringens 120-Kilodalton Collagenase and Nucleotide Sequence of the Corresponding Gene ,
J Bacteriol
 176 , 149 , 1994
Matsushita, O. , Jung, C. , Katayama, S. , Minami, J. , Takahashi, Y. and Okabe, A.
Gene Duplication and Multiplicity of Collagenases in Clostridium histolyticum ,
J Bacteriol
 181 , 923 , 1999
McCroskery, P. , Wood, S. and Harris, E.
Gelatin: A Poor Substrate for Mammalian Collagenase ,
Science
 182 , 70 , 1973
McCroskery, P. , Richards, J. and Harris, E.
Purification and Characterization of Collagenase Extracted from Rabbit Tumours ,
Biochem J
 152 , 131 , 1975
McGowan, J. , Strain, A. and Bucher, N.
DNA Synthesis in Primary Cultures of Rat Hepatocytes in Defined Medium: Effects of Epidermal Growth Factor, Insulin,Glucagon, and Cyclic-AMP ,
J Cell Physiol
 108 , 353 , 1981
Merkel, J. , Dreisbach, J. and Ziegler, H.
Collagenolytic Activity of Some Marine Bacteria ,
Appl Microbiol
 29 , 145 , 1975
Michaels, S. , Gallop, P. , Seifter, S. and Meilman, E.
Studies on the Specificity of Collagenase ,
Biochim Biophys Acta
 29 , 450 , 1958
Mitchell, W.
Pseudocollagenase: A Protease from Clostridium histolyticum ,
Biochim Biophys Acta
 159 , 554 , 1968
Mitić, R. , Cantoni, F. , Börlin, C. , Post, M. and Jackisch, L.
A Simplified and Defined Serum-free Medium for Cultivating Fat Across Species. , iScience Vol. 26 , 105822 , 2023
Miyahara, M. , Hayashi, K. , Berger, J. , Tanzawa, K. , Njieha, F. , Trelstad, R. and Prockop, D.
Formation of Collagen Fibrils by Enzymatic Cleavage of Precursors of Type I Collagen in vitro ,
J Biol Chem
 259 , 9891 , 1984
Mookhtiar, K. , Steinbrink, D. and Van Wart, H.
Mode of Hydrolysis of Collagen-Like Peptides by Class I and Class II Clostridium histolyticum Collagenases: Evidence for Both Endopeptidase and Tripeptidyl-Carboxypeptidase Activities ,
Biochemistry
 24 , 6527 , 1985
Moore, S. and Stein, W.
Photometric Ninhydrin Method for Use in the Chromatography of Amino Acids ,
J Biol Chem
 176 , 367 , 1948
Moore, W. and Spilburg, C.
Purification of Human Collagenases with a Hydroxamic Acid Affinity Column ,
Biochemistry
 25 , 5189 , 1986
Morris, G.
A High Molecular Weight Collagenase Inhibitor Made by Rabbit Chondrocytes in Cell Culture ,
Matrix
 9 , 127 , 1989
Moskalewski, S.
Beginning of Pancreatic Islet Isolation by Collagenase Digestion (personal reminiscences) ,
Ann Transplant
 2 , 6 , 1997
Murphy, G. , McAlpine, C. , Poll, C. and Reynolds, J.
Purification and Characterization of a Bone Metalloproteinase that Degrades Gelatin and Types IV and V Collagen ,
Biochim Biophys Acta
 831 , 49 , 1985
Nagai, N. , Yunoki, S. , Satoh, Y. , Tajima, K. and Munekata, M.
A Method of Cell-Sheet Preparation Using Collagenase Digestion of Salmon Atelocollagen Fibrillar Gel ,
J Biosci Bioeng
 98 , 493 , 2004
Nagai, Y. , Lapiere, C. and Gross, J.
Tadpole Collagenase: Preparation and Purification ,
Biochemistry
 5 , 3123 , 1966
Nagai, Y.
Specificity of Collagenase. The Action of Collagenase on Synthetic Peptides ,
J. Biochem.
 50 , 493 , 1961
Nagase, H. , Cawston, T. , DeSilva, M. and Barrett, A.
Identification of Plasma Kallikrein as an Activator of Latent Collagenase in Rheumatoid Synovial Fluid ,
Biochim Biophys Acta
 702 , 133 , 1982
Nagase, H. , Harris, E. , Woessner, J. and Brew, K.
Ovostatin: A Novel Proteinase Inhibitor from Chicken Egg White. I. Purification, Physicochemical Properties, and Tissue Distribution of Ovostatin ,
J Biol Chem
 258 , 7481 , 1983
Nagase, H. , Jackson, R. , Brinckerhoff, C. , Vater, C. and Harris, E.
A Precursor Form of Latent Collagenase Produced in a Cell-free System with mRNA from Rabbit Synovial Cells ,
J Biol Chem
 256 , 11951 , 1981
Nagase, H. and Harris, E.
Ovostatin: A Novel Proteinase Inhibitor From Chicken Egg White. II. Mechanism of Inhibition Studied with Collagenase and Thermolysin ,
J Biol Chem
 258 , 7490 , 1983
Narinesingh, D. and Ngo, T.
Enzyme Amplified Potentiometric Assay for Collagenase Using Urease-Labelled, Solid Supported Substrate ,
Anal Letters
 22 , 323 , 1989
Nedergaard, J. and Lindberg, O.
The Brown Fat Cell ,
Int Rev Cytol
 74 , 187 , 1982
Niedermuller, H. and Petersen, R.
Modification of Collagenase Activity in the Skin of Young, Adult and Old Rats by a Plasma Factor ,
Arch Gerontol Geriatrics
 Suppl. 1 , 277 , 1992
Nimni, M.
A Defect in the Intramolecular and Intermolecular Cross-linking of Collagen Caused by Penicillamine. I. Metabolic and Functional Abnormalities in Soft Tissues ,
J Biol Chem
 243 , 1457 , 1968
Nixon, J. , Bottomley K. , Broadhurst, M. , Brown, P. , Johnson, W. , Lawton, G. , Marley, J. , Sedgwick, A. and Wilkinson, S.
Potent Collagenase Inhibitors Prevent Interleukin-1-Induced Cartilage Degradation in vitro ,
Intl J Tissue Reac-Exp Clin
 13 , 237 , 1991
Noel, J. , Rabinovitch, A. , Olson, L. , Kyriakides, G. , Miller, J. and Mintz, D.
A Method for Large-Scale, High-Yield Isolation of Canine Pancreatic Islets of Langerhans ,
Metabolism
 31 (2) , 184 , 1982
Norfleet, W, Paglieara, A, Haymond, M, Matschinsky, F.
Comparison of Alpha- and Beta-Cell Secretory responses in Islets Isolated with Collagenase and in the Isolated Perfused Pancreas of Rats ,
Diabetes
 24 , 961 , 1975
Peck, W. , Birge, S. and Fedak, S.
Bone Cells: Biochemical and Biological Studies After Enzymatic Isolation ,
Science
 146 , 1476 , 1964
Peterkofsky, B. and Diegelmann, R.
Use of a Mixture of Proteinase-Free Collagenases for the Specific Assay of Radioactive Collagen in the Presence of Other Proteins ,
Biochemistry
 10 , 988 , 1971
Phillips, J. and Dresden, M.
A Collagenase in Extracts of the Invertebrate Bipalium kewense ,
Biochem J
 133 , 329 , 1973
Pollard, M. and Starr, T.
Propagation of Duck Hepatitis Virus in Tissue Cultures Prepared with Collagenase ,
J Bacteriol
 80 , 571 , 1960
Robertson, P. , Taylor, R. and Fullmer, H.
A Reproducible Quantitative Collagenase Radiofibril Assay ,
Clin Chim Acta
 42 , 43 , 1972
Robertson, P. and Miller, E.
Cartilage Collagen: Inability to Serve as a Substrate for Collagenases Active Against Skin and Bone Collagen ,
Biochim Biophys Acta
 289 , 247 , 1972
Rodbell, M.
Metabolism of Isolated Fat Cells. I. Effects of Hormones on Glucose Metabolism and Lipolysis ,
J Biol Chem
 239 (2) , 375 , 1964
Ryan, J. and Woessner, J.
Mammalian Collagenase: Direct Demonstration in Homogenates of Involuting Rat Uterus ,
Biochem Biophys Res Commun
 44 , 144 , 1971
Sakai, T. and Gross, J.
Some Properties of the Products of Reaction of Tadpole Collagenase with Collagen ,
Biochemistry
 6 , 518 , 1967
Sakamoto, S. , Goldhaber, P. and Glimcher, M.
A New Method for the Assay of Tissue Collagenase ,
Proc Soc Exp Biol Med
 139 , 1057 , 1972
Sakamoto, S. , Sakamoto, M. , Goldhaber, P. and Glimcher, M.
Collagenase and Bone Resorption: Isolation of Collagenase from Culture Medium Containing Serum After Stimulation of Bone Resorption by Addition of Parathyroid Hormone Extract ,
Biochem Biophys Res Commun
 63 , 172 , 1975
Sakamoto, S. , Sakamoto, M. , Goldhaber, P. and Glimcher, M.
Isolation of Tissue Collagenase From Homogenates of Embryonic Chick Bones ,
Biochem Biophys Res Commun
 53 , 1102 , 1973
Sakamoto, S. , Sakamoto, M. , Goldhaber, P. and Glimcher, M.
Studies on the Interaction Between Heparin and Mouse Bone Collagenase ,
Biochim Biophys Acta
 385 , 41 , 1975
Schaub, M. and Strauch, L.
Evidence for a New Bacterial Collagenolytic Enzyme ,
Biochem Biophys Res Commun
 21 , 34 , 1965
Schaub, M. and Strauch, L.
Purification of Collagenase IV. Separation and Identification of Clostridial Collagenases by Disc Electrophoresis on Polyacrylamide Gel ,
Hoppe Seylers Z Physiol Chem
 349 , 809 , 1968
Schoellmann, G. and Fisher, E.
A Collagenase From Pseudomonas aeruginosa ,
Biochim Biophys Acta
 122 , 557 , 1966
Seglen, P.
Preparation of Rat Liver Cells II. Effects of Ions and Chelators on Tissue Dispersion ,
Exp Cell Res
 76 , 25 , 1973
Seifter, S. and Gallop, P.
, The Proteins, 2nd ed Vol. Vol. IV , H. Neurath , Academic Press, NY , 238 , 1966
Seifter, S. and Harper, E.
Collagenases , Methods in Enzymology Vol. 19 , G. Perlmann and L. Lorand , Academic Press, NY , 613 , 1970
Seifter, S. and Harper, E.
Collagenases , The Enzymes Vol. 3 , P. Boyer , Academic Press, NY , 649 , 1971
Seifter, S. , Gallop, P. , Klein, L. and Meilman, E.
Studies on Collagen II. Properties of Purified Collagenase and its Inhibitor ,
J Biol Chem
 234 , 285 , 1959
Seifter, S. , Takahasi, S. and Harper, E.
Further Demonstration that Cysteine Reacts with the Metal Component of Collagenase ,
Biochim Biophys Acta
 214 , 559 , 1970
Sgaragli, G. , Sen, I. , Baba, A. , Schulz, R. and Cooper, J.
The Mechanism of Action of Collagenase on the Inhibition of Release of Acetylcholine from Synaptosomal Preparations ,
Brain Res
 134 , 113 , 1977
Shibata, A. , Ludvigsen, C. , Naber, S. , McKaneil M. and Lacy, P.
Standardization of a Digestion-Filtration Method for Isolation of Islets ,
Diabetes
 25 , 667 , 1976
Soberano, M. and Schoellmann, G.
Specificity of Bacterial Collagenase: Studies with Peptides Newly Synthesized Using the Solid-Phase Method ,
Biochim Biophys Acta
 271 , 133 , 1972
Soberano, M. and Schoellmann, G.
Anomalous Kinetics Observed in the Catalysis of a Peptide Substrate with Collagenase ,
Biochim Biophys Acta
 289 , 401 , 1972
Soru, E. and Zaharia, O.
Clostridium histolyticum Collagenase. II. Partial Characterization ,
Enzymologia
 43 , 45 , 1972
Sparrow, L. and McQuade, A.
Isolation by Affinity Chromatography of Neutral Proteinase from Clostridium histolyticum ,
Biochim Biophys Acta
 302 , 90 , 1973
Spina, M. , Garbin, G. , Field, J. and Serafini-Fracassini, A.
The Application of Collagenase, Purified by Affinity Chromatography, to the Isolation of Insoluble Elastin from Bovine Aorta ,
Biochim Biophys Acta
 400 , 162 , 1975
Stack, M. and Gray, R.
Comparison of Vertebrate Collagenase and Gelatinase Using a New Fluorogenic Substrate Peptide ,
J Biol Chem
 264 , 4277 , 1989
Steinbrink, D. , Bond, M. and Van Wart, H.
Substrate Specificity of beta-Collagenase from Clostridium histolyticum ,
J Biol Chem
 260 , 2771 , 1985
Steven, F. , Knott, J. , Jackson, D. and Podrazky, V.
Collagen-Protein-Polysaccharide Interactions in Human Intervertebral Disc ,
Biochim Biophys Acta
 188 , 307 , 1969
Stricklin, G. and Welgus, H.
Human Skin Fibroblast Collagenase Inhibitor. Purification and Biochemical Characterization ,
J Biol Chem
 258 , 12252 , 1983
Sugasawara, R. and Harper, E.
Purification and Characterization of Three Forms of Collagenase from Clostridium histolyticum ,
Biochemistry
 23 , 5175 , 1984
Sussman, B.
Intervertebral Discolysis with Collagenase ,
JAMA
 60 , 184 , 1968
Takahashi, S. and Seifter, S.
Dye-Sensitized Photo-Inactivation of Collagenase A ,
Biochim Biophys Acta
 214 , 556 , 1970
Tanaka, T. , Metori, K. , Mineo, S. , Hirotani, M. , Furuya, T. , Matsumoto, H. , Satoh, T. and Kobayashi, S.
Studies on Collagenase Inhibitors. IV. Inhibitors of Bacterial Collagenase in Coptidis rhizoma ,
J Pharm Soc Japan
 111 , 538 , 1991
Tanzer, M.
Cross-Linking of Collagen ,
Science
 180 , 561 , 1973
Taylor, A. , Levy, B. and Simpson, J.
Collagenolytic Activity of Sarcoma Tissues in Culture ,
Nature
 228 , 366 , 1970
Thompson, M. , Shuplock, N. and Fetterman, S.
Collagenase Method of Renal Microdissection. Preservation of Nuclear Staining ,
Arch Pathol
 78 , 568 , 1964
Tokoro, Y. , Eisen, A. and Jeffrey, J.
Characterization of a Collagenase from Rat Skin ,
Biochim Biophys Acta
 258 , 289 , 1972
Tong, N. , Tsugita, A. and Keil-Dlouha, V.
Purification and Characterization of Two High-Molecular-Mass Forms of Achromobacter Collagenase ,
Biochim Biophys Acta
 874 , 296 , 1986
Toyoshima, T. , Matsushita, O. , Minami, J. , Nishi, N. , Okabe, A. and Itano, T.
Collagen-Binding Domain of a Clostridium histolyticum Collagenase Exhibits a Broad Substrate Spectrum Both in vitro and in vivo , Connect Tissue Res Vol. 42 , 281 , 2001
Treadwell, B. , Neidel, J. , Pavia, M. , Towle, C. , Trice, M. and Mankin, H.
Purification and Characterization of Collagenase Activator Protein Synthesized by Articular Cartilage ,
Arch Biochem Biophys
 251 , 715 , 1986
Treadwell, B. , Towle, C. , Ishizue, K. , Mankin, K. , Pavia, M. , Ollivierre, F. and Gray, D.
Stimulation of the Synthesis of Collagenase Activator Protein in Cartilage by a Factor Present in Synovial-Conditioned Medium ,
Arch Biochem Biophys
 251 , 724 , 1986
Trusler, S.
Letter: G Bands Produced by Collagenase ,
Lancet
 305 , 44 , 1975
Vaes, G.
The Release of Collagenase as an Inactive Proenzyme by Bone Explants in Culture ,
Biochem J
 126 , 275 , 1972
Vaitkevicius, V. , Simpson, W. and Brennan, M.
Freeze Preservation of Enzymatically Prepared Tumor Cell Suspensions and Their Use in Tumor Transplantation ,
Cancer Res
 21 , 187 , 1961
Van Wart, H. and Steinbrink, D.
Complementary Substrate Specificities of Class I and Class II Collagenases from Clostridium histolyticum ,
Biochemistry
 24 , 6520 , 1985
Van Wart, H. and Steinbrink, D.
A Continuous Spectrophotometric Assay for Clostridium histolyticum Collagenase ,
Anal Biochem
 113 , 356 , 1981
Van Wart, H.
Clostridium Collagenases , in Handbook of Proteolytic Enzymes , (Barrett, A., Rawlings, N., and Woessner, J., eds.) , Academic Press, London and San Diego , 416 , 1998
Vencill, C. , Rasnick, D. , Crumley, K. , Nishino, N. and Powers, J.
Clostridium histolyticum Collagenase: Development of New Thio Ester, Flurogenic, and Depsipeptide Substrates and New Inhbitors ,
Biochemistry
 24 , 3149 , 1985
Verheijen, J. , Nieuwenbroek, N. , Beekman, B. , Hanemaaijer, R. , Verspaget, H. , Ronday, H. and Bakker, A.
Modified Proenzymes as Artificial Substrates for Proteplytic Enzymes: Colorimetric Assay of Bacterial Collagenase and Matrix Metalloproteinase Activity Using Modified Pro-Urokinase ,
Biochem J
 323 , 603 , 1997
von Hippel, P. , Gallop, P. , Seifter, S. and Cunningham, R.
An Enzymatic Examination of the Structure of the Collagen Macromolecule ,
J Am Chem Soc
 82 , 2774 , 1960
Vos-Scheperkeuter, G. , Vonk, M. , Wolters, G. and van Schilfgaarde, R.
Collagen Degradation by Three Clostridium histolyticum Collagenase Fractions with Different Substrate Specificities. ,
Transplant Proc
 26 , 641 , 1994
Wahl, L. , Wahl, S. , Mergenhagen, S. and Martin, G.
Collagenase Production by Lymphokine-Activated Macrophages ,
Science
 187 , 261 , 1975
Warren, G. and Gray, J.
A Simplified Culture Medium for the Production of Collagenase ,
Nature
 192 , 755 , 1961
Weingarten, H. , Martin, R. and Feder, J.
Synthetic Substrates of Vertebrate Collagenase ,
Biochemistry
 24 , 6730 , 1985
Welgus, H. and Stricklin, G.
Human Skin Fibroblast Collagenase Inhibitor. Comparative Studies in Human Connective Tissues, Serum and Amniotic Fluid ,
J Biol Chem
 258 , 12259 , 1983
Welgus, H. , Jeffrey, J. and Eisen, A.
Human Skin Fibroblast Collagenase. Assessment of Activation Energy and Deuterium Isotope Effect with Collagenous Substrates ,
J Biol Chem
 256 , 9516 , 1981
Welton, R. and Woods, D.
Halotolerant Collagenolytic Activity of Achromobacter iophagus ,
J Gen Microbiol
 75 , 191 , 1973
Welton, R. and Woods, D.
Collagenase Production by Achromobacter iophagus ,
Biochim Biophys Acta
 384 , 228 , 1975
Werb, Z. and Burleigh, M.
A Specific Collagenase from Rabbit Fibroblasts in Monolayer Culture ,
Biochem J
 137 , 373 , 1974
Werb, Z. , Burleigh, M. , Barrett, A. and Starkey, P.
The Interaction of alpha-2-Macroglobulin with Proteinases. Binding and Inhbition of Mammalian Collagenase and Other Metal Proteinases ,
Biochem J
 139 , 359 , 1974
Wize, J.
A Latent Collagenase from Rheumatoid Synovial Fluid. Purification and Partial Characterization ,
Biochim Biophys Acta
 615 , 199 , 1980
Woessner, J. and Ryan, J.
Collagenase Activity in Homogenates of the Involuting Rat Uterus ,
Biochim Biophys Acta
 309 , 397 , 1973
Wolf, G.
The Molecular Basis of the Inhibition of Collagenase by Vitamin A ,
Nutr Rev
 50 , 292 , 1992
Wolters, G. , Vos-Scheperkeuter, G. , van Deijnen, J. and van Schilfgaarde, R.
An Analysis of the Role of Collagenase and Protease in the Enzymatic Dissociation of the Rat Pancreas for Islet Isolation ,
Diabetologia
 35 , 735 , 1992
Woolley, D. , Lindberg, K. , Glanville, R. and Evanson, J.
Action of Rheumatoid Synovial Collagenase on Cartilage Collagen. Different Susceptibilities of Cartilage and Tendon Collagen to Collagenase Attack ,
Eur J Biochem
 50 , 437 , 1975
Woolley, D. , Roberts, D. and Evanson, J.
Inhibition of Human Collagenase Activity by a Small Molecular Weight Serum Protein ,
Biochem Biophys Res Commun
 66 , 747 , 1975
Woolley, D. , Roberts, D. and Evanson, J.
Small Molecular Weight beta 1 Serum Protein which Specifically Inhibits Human Collagenases ,
Nature
 261 , 325 , 1976
Woolley, F. , Glanville, R. , Crossley, M. and Evanson, J.
Purification of Rheumatoid Synovial Collagenase and Its Action on Soluble and Insoluble Collagen ,
Eur J Biochem
 54 , 611 , 1975
Wuensch, E. and Heidrich, H.
On the Quantitative Determination of Collagenase ,
Hoppe Seylers Z Physiol Chem
 333 , 149 , 1963
Wuensch, E. and Heidrich, H.
Demonstration of Proline Peptides. III. A New Substrate for Determination of Collagenase ,
Hoppe Seylers Z Physiol Chem
 332 , 300 , 1963
Yagisawa, S. Morita, F. , Nagai, Y. , Noda, H. and Ogura, Y.
Kinetic Studies on the Action of Collagenase ,
J. Biochem.
 58 , 407 , 1965
Yiotakis, A. , Hatgiyannacou, A. , Dive, V. and Toma, F.
New Thiol Inhibitors of Clostridium histolyticum Collagenase - Importance of the P3' Position ,
Eur J Biochem
 172 , 761 , 1988
Yoshida, E. and Noda, H.
Isolation and Characterization of Collagenases I and II from Clostridium histolyticum ,
Biochim Biophys Acta
 105 , 562 , 1965
Yoshihara, K. , Matsushita, O. , Minami, J. and Okabe, A.
Cloning and Nucleotide Sequence Analysis of the colH Gene from Clostridium histolyticum Encoding a Collagenase and a Gelatinase ,
J Bacteriol
 176 , 6489 , 1994
Zimmerman, W.
The Importance of Collagenase for the Local Treatment of Major Burns , Collagenase , I. Mandl , Gordon and Breach, NY , 131 , 1972

Collagenase Products

Description
Activity
Code
Cat. #
Size
Price
Description
Collagenase, Purified
Source:
Clostridium histolyticum
Chromatographically purified. ≤ 50 caseinase units per milligram. Supplied as a lyophilized powder.
Store at 2-8°C.
…
Activity
≥500 units per mg dry weight
Code
CLSPA
LS005275
4 ku
$98.00
LS005273
10 ku
$198.00
LS005277
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 100000 x 1 un. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase Vial, NCIS
Source:
Clostridium histolyticum
A component of the NCIS kit. This material is 0.22 micron membrane filtered and lyophilized in autoclaved vials. A vial reconstituted with 5 ml of HBSS or equivalent yields a solution of 300 units/ml of purified collagenase. Suitable for cell isolation and culture applications.
Store at 2-8°C.
…
Activity
≥500 units per mg dry weight
Code
CLSPANK
LK003240
1 vi
$35.00
LK003245
5 vi
$145.00
Description
Collagenase/Elastase Vial (CLSH)
Source:
Clostridium histolyticum
Enzyme vial of HIS kit that contains 20,000 units of collagenase (Code: CLS-1) and 30 units of elastase (Code: ESL), filtered through 0.22 micron membrane and lyophilized.
Store at 2-8°C.
…
Activity
≥20,000 units collagense/30 units elastase per vial
Code
CLSH
LK002067
5 vi
$260.00
LK002066
1 vi
$60.00
Description
Collagenase, Type 1
Source:
Clostridium histolyticum
The original balance of enzymatic activities. Each lot assayed for collagenase, caseinase, clostripain and tryptic activities. Suggested for epithelial, liver, lung and adrenal primary cell isolations. A dialyzed, lyophilized powder.
Store at 2-8°C.
…
Activity
≥125 units per mg dry weight
Code
CLS-1
LS004194
100 mg
$42.00
LS004196
1 gm
$215.00
LS004197
5 gm
$900.00
LS004200
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Type 2
Source:
Clostridium histolyticum
Prepared to contain higher clostripain activity. Suggested for bone, heart, liver, thyroid and salivary primary cell isolation. Supplied as a dialyzed, lyophilized powder.
Store at 2-8°C.
…
Activity
≥125 units per mg dry weight
Code
CLS-2
LS004174
100 mg
$42.00
LS004176
1 gm
$215.00
LS004177
5 gm
$900.00
LS004179
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Type 3
Source:
Clostridium histolyticum
Lower in secondary proteolytic contaminant activities but with typical collagenase activity. Suggested for mammary primary cell isolation. A dialyzed, lyophilized powder.
Store at 2-8°C.
…
Activity
≥100 units per mg dry weight
Code
CLS-3
LS004180
100 mg
$42.00
LS004182
1 gm
$215.00
LS004183
5 gm
$900.00
LS004185
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Type 4
Source:
Clostridium histolyticum
Prepared to contain lower tryptic activity levels to limit damage to membrane proteins and receptors but with normal to above normal collagenase activity. Suggested for pancreatic islet primary isolation. A dialyzed, lyophilized powder.
Store at 2-8°C.
…
Activity
≥160 units per mg dry weight
Code
CLS-4
LS004186
100 mg
$42.00
LS004188
1 gm
$215.00
LS004189
5 gm
$900.00
LS004191
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Type 5
Source:
Clostridium histolyticum
Partially purified to contain higher collagenase and caseinase activities. A dialyzed, lyophilized powder.
Store at 2-8°C.
…
Activity
≥450 units per mg dry weight
Code
CLS-5
LS005280
100 mg
$51.00
LS005282
1 gm
$246.00
LS005283
5 gm
$1,040.00
LS005284
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Type 6
Source:
Clostridium histolyticum
Prepared to contain above normal collagenase, FALGPA and Caseinase activities and designed to be enriched with Type II (col H) collagenase.
Store at 2-8°C.
…
Activity
≥400 units per milligram dry weight
Code
CLS-6
LS005318
100 mg
$60.00
LS005319
500 mg
$230.00
LS005321
2.5 gm
$660.00
LS005323
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 25000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Type 7
Source:
Clostridium histolyticum
Prepared to contain 4-5X more collagenase, FALGPA and Caseinase activities than Collagenase 1-4 and with moderate clostripain and tryptic activities.
 
 
Store at 2-8°C.
…
Activity
≥1,000 units per milligram dry weight
Code
CLS-7
LS005332
100 mg
$68.00
LS005333
500 mg
$260.00
LS005335
2.5 gm
$750.00
LS005337
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 25000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Type 1, Filtered
Source:
Clostridium histolyticum
Collagenase, Type 1 (Code: CLS-1), which is filtered through a 0.22 micron membrane and lyophilized in vials.
Store at 2-8°C.
…
Activity
≥125 units per mg dry weight
Code
CLSS-1
LS004214
50 mg
$55.00
LS004216
5x50 mg
$200.00
LS004217
1 gm
$490.00
Description
Collagenase, Type 2, Filtered
Source:
Clostridium histolyticum
Collagenase, Type 2 (Code: CLS-2), which is filtered through a 0.22 micron membrane and lyophilized in vials.
Store at 2-8°C.
…
Activity
≥125 units per mg dry weight
Code
CLSS-2
Minimum order quantity
10000
LS004203
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 10000 x 50 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
LS004202
50 mg
$55.00
LS004204
5x50 mg
$200.00
LS004205
1 gm
$490.00
Description
Collagenase, Type 3, Filtered
Source:
Clostridium histolyticum
Collagenase, Type 3 (Code: CLS-3), which is filtered through a 0.22 micron membrane and lyophilized in vials to contain 50 milligrams per vial.
Store at 2-8°C.
…
Activity
≥100 units per mg dry weight
Code
CLSS-3
LS004206
50 mg
$55.00
LS004208
5x50 mg
$200.00
Description
Collagenase, Type 4, Filtered
Source:
Clostridium histolyticum
Collagenase, Type 4 (Code: CLS-4), which is filtered through a 0.22 micron membrane and lyophilized in vials.
Store at 2-8°C.
…
Activity
≥160 units per mg dry weight
Code
CLSS-4
LS004210
50 mg
$55.00
LS004212
5x50 mg
$200.00
LS004209
1 gm
$490.00
Description
Collagenase, Type 5, Filtered
Source:
Clostridium histolyticum
Collagenase Type 5 (Code: CLS-5), which is filtered through a 0.22 micron membrane and lyophilized in vials.
Store at 2-8°C.
…
Activity
≥450 units per mg dry weight
Code
CLSS-5
LS005286
50 mg
$64.00
LS005287
5x50 mg
$227.00
LS005288
1 gm
$572.00
Description
Collagenase CLSAFA AF
Source:
Clostridium histolyticum
Collagenase Animal Free/AF is prepared from cultures grown in a medium devoid of animal based components with similar collagenase and secondary proteases to CLS-1 and CLS-2.
Store at 2-8°C.
…
Activity
≥150 units per mg dry weight
Code
CLSAFA
LS004152
100 mg
$53.00
LS004154
1 gm
$258.00
LS004156
5 gm
$1,100.00
LS004158
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, CLSAFA, Filtered, AF
Source:
Clostridium histolyticum
Collagenase, Animal Free/AF (Code: CLSAFA) which is filtered through a 0.22 micron membrane and lyophilized in vials.
Store at 2-8°C.
…
Activity
≥150 units per mg dry weight
Code
CLSAFAS
LS004118
50 mg
$72.00
LS004119
5x50 mg
$300.00
LS004123
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 10000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase CLSAFB AF
Source:
Clostridium histolyticum
Collagenase Animal Free/AF is prepared from cultures grown in medium devoid of animal based components to contain higher collagenase and caseinase activities than CLSAFA. 
Store at 2-8°C.
…
Activity
≥300 units per mg dry weight
Code
CLSAFB
LS004145
100 mg
$53.00
LS004147
1 gm
$258.00
LS004148
5 gm
$1,100.00
LS004150
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, CLSAFB, Filtered, AF
Source:
Clostridium histolyticum
Collagenase, Animal Free/AF (Code: CLSAFB) which is filtered through a 0.22 micron membrane and lyophilized in vials.
Store at 2-8°C.
…
Activity
≥300 units per mg dry weight
Code
CLSAFBS
LS004124
50 mg
$72.00
LS004125
5x50 mg
$300.00
LS004129
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 10000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase CLSAFC AF
Source:
Clostridium histolyticum
Collagenase Animal Free/AF is prepared from cultures grown in a medium devoid of animal based components to contain especially low tryptic activity similar to CLS-4.
Store at 2-8°C.
…
Activity
≥200 units per mg dry weight
Code
CLSAFC
LS004138
100 mg
$53.00
LS004140
1 gm
$258.00
LS004141
5 gm
$1,100.00
LS004143
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 50000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, CLSAFC, Filtered, AF
Source:
Clostridium histolyticum
Collagenase Animal Free/AF (Code: CLSAFC) which is filtered through a 0.22 micron membrane and lyophilized in vials.
Store at 2-8°C.
…
Activity
≥200 units per mg dry weight
Code
CLSAFCS
LS004130
50 mg
$72.00
LS004131
5x50 mg
$300.00
LS004135
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 10000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
Collagenase, Purified, Animal Free
Source:
Clostridium histolyticum
Prepared from cultures grown in medium completely devoid of animal based components and designed for bioprocessing applications where introduction of animal derived pathogens must be prevented.  Chromatographically purified.  ≤ 50 caseinase units per milligram. Supplied as a lyophilized powder.
Store at 2-8°C.
…
Activity
≥1,500 units per mg dry weight
Code
CLSAFP
Minimum order quantity
100
LS005294
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 100 x 1 ku. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
LS005290
4 ku
$95.00
LS005292
10 ku
$195.00
Description
Collagenase CLSAFD AF
Source:
Clostridium histolyticum
Collagenase Animal Free/AF is prepared from cultures grown in a medium devoid of animal based components to contain two to three fold higher specific activity than CLSAFA. 
Store at 2-8°C.
…
Activity
---
Code
CLSAFD
LS004160
100 mg
$68.00
LS004162
500 mg
$275.00
LS004163
2500 mg
$1,315.00
LS004165
Bulk
---
The minimum amount for bulk packaging/pricing for this product is 25000 x 1 mg. Please contact custservice@worthington-biochem.com to request a quote for smaller amounts.
Description
STEMxyme® 1, Collagenase/Neutral Protease (Dispase), AF
Source:
Clostridium histolyticum/Bacillus polymyxa
A specialized combination of Animal Free Clostridium histolyticum collagenase (Code: CLSAFB) and animal free Bacillus polymyxa neutral protease with a minimum of 250 CLS units and 1,000 caseinase units per mg dry weight. Designed for stem cell and other primary cell isolations and bioprocessing applications where introduction of potential animal derived pathogens must be prevented.
Store at 2-8°C.
…
Activity
≥250 CLS/1,000 CAS units per milligram dry weight
Code
STZ1
LS004106
50 mg
$110.00
LS004107
5x50 mg
$495.00
Description
STEMxyme® 2 Collagenase/Neutral Protease (Dispase), AF
Source:
Clostridium histolyticum/Bacillus polymyxa
A specialized combination of Animal Free Clostridium histolyticum collagenase (Code: CLSAFB) and animal free Bacillus polymyxa neutral protease with a minimum of 250 CLS units and 2,000 caseinase units per mg dry weight. Designed for stem cell and other primary cell isolations and bioprocessing applications where introduction of potential animal derived pathogens must be prevented.
Store at 2-8°C.
…
Activity
≥250 CLS/2,000 CAS units per milligram dry weight
Code
STZ2
LS004112
50 mg
$164.00
LS004113
5x50 mg
$725.00
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